Both The Folate Therapy and the Folate Treatment Combined with Zinc Had an Effect on the Endocrine Markers and Sperm Characteristics of Sub-Fertile Males

Aim: The purpose of this study was to see how folate and + zinc treatment affected endocrine markers sperm properties in sub fertile males. Methods: methodical research addition meta-analysis carried out. From 1969 May 2020, databases were searched by Medline, Scopus, Google scholar, Persian have been examined that used the set pertinent keywords comprising "folate or folic acid AND (infertility, infertile, sterile)". Any standardized clinical studies took oral plus on a selection males for semen analysis are included the. Endocrine characteristics parameters among information gathered. Comprehensive Meta-analysis Version 2 data methods. Results: Eight researches remained comprised total. Seven enough meta-analysis. "Sperm concentration significantly greater treated using than men not supplied (P.002)." Furthermore, supplementation unaided did appear remain additional beneficial placebo terms morphology (P =.057) motility =.653). In comparison placebo, with dietary had no measurable difference blood testosterone =.87), inhibin B =.85), FSH =.056), =.168). However, as given substantially bigger influence (P.002), level (P.002). Conclusion: Folate improves qualities infertile men. Nonetheless, because significant heterogeneity papers meta-analysis, those findings must be regarded care. More is necessary corroborate existing results. Keywords: Effect Folate, Plus Zinc Supplementation, properties,